Osteolytic lesions (lesions in the bone) caused by myeloma are used to measure the progression of cancer within a host. Previous processes for quantifying these lesions were manual, subjective and often lead to a high variability in results even when using identical samples. The Osteolytica software developed within the ACRC uses advance image registration techniques and graphics hardware acceleration to essentially reconstruct the original bone volume before the onset of osteolytic lesions. The result is visualised as a 3D volumetric model in real-time. This approach, for the first time, gives researchers a fast and standard way to accurately quantify bone loss by surface area.